AP39 THROUGH AMPK-ULK1-FUNDC1 PATHWAY REGULATES MITOPHAGY, INHIBITS PYROPTOSIS, AND IMPROVES DOXORUBICIN-INDUCED MYOCARDIAL FIBROSIS

AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis

Summary: Doxorubicin induces myocardial injury and fibrosis.Still, no effective interventions are available.AP39 is an H2S donor that explicitly targets mitochondria.This study investigated whether Tables AP39 could improve doxorubicin-induced myocardial fibrosis.Doxorubicin induced significant myocardial fibrosis while suppressing mitophagy-relate

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Assessment of a New GC-MS/MS System for the Confirmatory Measurement of PCDD/Fs and (N)DL-PCBs in Food under EU Regulation

Polychlorodibenzo-p-dioxins (PCDDs), polychloro-dibenzofurans (PCDFs), dioxin-like (DL), and non dioxin-like (NDL) polychlorinated biphenyls (PCBs) are currently regulated in food and feed within the European territory (EU 2017/644-771).The confirmatory methods of analysis for checking compliance with maximum levels (MLs) for these involve either t

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THE NEED(LESSNESS) OF REGULATION ABOUT THE COLLECTIVE DISMISSAL IN BRAZIL: AN ANALYSIS UNDER THE PERSPECTIVE OF SOCIAL VALUE OF WORK AND HUMAN DIGNITY

In the current Brazilian scenario, it is not uncommon to report the occurrence of collective dismissals involving a large number of workers.The justifications are based on factors Dot Matrix Printer linked to the economic situation of the country.In this context, this paper aims to examine the arbitrary collective dismissal, under the perspective o

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What Matters for Comovements among Gold, Bitcoin, CO2, Commodities, VIX and International Stock Markets during the Health, Political and Bank Crises?

This paper analyzes the connectedness between gold, wheat, and crude oil futures, Bitcoin, carbon emission futures, and international stock markets in the G7, BRICS, and Gulf regions with the outbreak of exogenous and unexpected shocks related to health, banking, and political crises.To this end, we use a wavelet-based method on the returns of diff

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